gallic acid antioxidant

XX is the XXth reference in the list of references. However, as with other cases, us… To find novel skin-whitening agents, the melanogenesis inhibitory action of gallic acid (GA) was investigated. Ethyl acetate extract from Panax ginseng C.A. In this present work, I attempted to investigate the effect of Gallic acid derivatives have also been found in a number of phytomedicines with diverse biological and pharmacological activities, including radical scavenging, interfering with the cell signaling pathways and apoptosis of cancer cells. This may take some time to load. To investigate the relation between GA's inhibition of melanogenesis and antioxidant activity, the effect of GA on reactive species (RS) generation and the reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio in were determined in B16 cells. Computational Chemistry Laboratory, Department of Chemistry, University of Delhi, Delhi-110007, India Results indicated that GA has a strong antityrosinase activity (IC50=3.59x10(-6) M). Mori T, Koyama N, Yokoo T, Segawa T, Maeda M, Sawmiller D, Tan J, Town T. J Biol Chem. Gallic acid seems to have anti-fungal and anti-viral properties. Gallic acid is a trihydroxybenzoic acid found in many plants as either the free acid or in the esterified form of gallotannins and ellagitannins. Epub 2013 Jun 4. Starting from the bioavailability and the biosynthetic pathway of gallic acid, this review includes various in vitro, in vivo and in silico studies providing the mode of action, radical scavenging activity, ability to inhibit lipid peroxidation, maintenance of endogenous defense systems and metal ion chelation by this triphenolic molecule, along with a comprehensive overview of factors responsible for its high antioxidant activity. Gallic acid acts as a antioxidant and helps to protect our cells against oxidative damage. Grape seeds and skins are good sources of phytochemicals such as gallic acid, catechin, and epicatechin and are suitable raw materials for the production of antioxidative dietary supplements. If you are the author of this article you still need to obtain permission to reproduce In addition, numerous studies have reported that antioxidants possess antiviral activities. Maxima in Antioxidant Distributions and Efficiencies with Increasing Hydrophobicity of Gallic Acid and Its Alkyl Esters. Among various polyphenols, gallic acid (3,4,5-trihydroxybenzoic acid), a naturally occurring low molecular weight triphenolic compound, has emerged as a … National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Gallic acid can also be used as a starting material in the synthesis of the psychedelic alkaloid mescaline. Fetching data from CrossRef. Gallic acid esters, such as tannins, catechin gallates and aliphatic gallates are potent antioxidants in vitro. NIH You do not have JavaScript enabled. Gallic acid is an antioxidant which can inhibit both COX-2. P53 and cancer Every cell in our body has a gene called TP53 which produces a protein called p53. This is followed by an account of their potential clinical and industrial applications. 2020 Oct 16;15:7995-8018. doi: 10.2147/IJN.S270242. It has a role as an astringent, a cyclooxygenase 2 inhibitor, a plant metabolite, an antioxidant, an antineoplastic agent, a human xenobiotic metabolite, an EC 1.13.11.33 ( arachidonate 15-lipoxygenase) inhibitor and an apoptosis inducer. Salts and esters of gallic acid are termed "gallates". Gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress and suppressing. COVID-19 is an emerging, rapidly evolving situation. Normal biochemical reactions, increased exposure to the environment, and higher levels of dietary xenobiotics result in the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS).2 ROS and RNS are responsible for the oxidative stress in different pathophysiological conditions.3 Cellular constituents of our body are altered in oxidative stress conditions, resulting in various disease states. 2020 Dec;58(1):590-596. doi: 10.1080/13880209.2020.1777169. 2.3. Oxidative stress, a result of an overproduction and accumulation of free radicals, is the leading cause of several degenerative diseases such as cancer, atherosclerosis, cardiovascular diseases, ageing and inflammatory diseases. The Pseudophase Model Interpretation of the “Cutoff Effect”. gallic acid—it could equally infer that gallic acid or delphini-din offers direct antioxidant protection resulting in protec-tion of GSH. it in a third party non-RSC publication you must Gallic acid (3,4,5-trihydroxy benzoic acid; GA) is a natural phenolic compound with low toxicity and is produced by dierent plants. This compound has antioxidant properties (an antioxidant is a substance that protects the body’s cells from the harmful free radicals) and helps to protect our cells against oxidative damage. eCollection 2020. Biol Pharm Bull. In all cases the Ref. Gallic acid was found to show cytotoxicity against cancer cells, without harming healthy cells. Antioxidant activity of extracts were expressed as percentage of DPPH radicals inhibition and IC50 values (µg/ml). Apart from its phytochemical role, gallic acid is also used in tanning, ink dyes, and the manufacture of paper. Go to our Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice. Authors contributing to RSC publications (journal articles, books or book chapters) Polyphenols form an important class of naturally occurring antioxidants, having innumerable biological activities such as anticancer, antifungal, antibacterial, antiviral, antiulcer and anticholesterol, to name a few. To find novel skin-whitening agents, the melanogenesis inhibitory action of gallic acid (GA) was investigated. Meyer and its main constituents inhibit α-melanocyte-stimulating hormone-induced melanogenesis by suppressing oxidative stress in B16 mouse melanoma cells. 2007 Nov;30(11):2007-11. doi: 10.1248/bpb.30.2007. Epub 2017 Jul 8. antioxidants Article Gallic Acid-Laminarin Conjugate Is a Better Antioxidant than Sulfated or Carboxylated Laminarin Marília Medeiros Fernandes-Negreiros 1, Lucas Alighieri Neves Costa Batista 1, Rony Lucas Silva Viana 1, Diego Araujo Sabry 1, Almino Afonso Oliveira Paiva 2, Weslley Souza Paiva 1, Raynara Iusk Araujo Machado 1, Francimar Lopes de Sousa Junior 3, HHS Gallic acid (GA), that is, 3,4,5-trihydroxybenzoic acid, is a naturally occurring polyphenol commonly found in a variety of fruits and vegetables such as grapes, green tea, tea leaves or tomatoes [ Materials. J Ethnopharmacol. Gallic acid … Free radicals may be the result of stress, diet, alcohol, prescription medications, smoking, physical exercise, inflammation, or exposure to air pollutants and sunlight. formally request permission using Copyright Clearance Center. It is a conjugate acid of a gallate. rkakkar@chemistry.du.ac.in Esmaeilzadeh M, Heidarian E, Shaghaghi M, Roshanmehr H, Najafi M, Moradi A, Nouri A. Pharm Biol. Deoxyribose assay. 2013;36(8):1341-7. doi: 10.1248/bpb.b13-00276. If you are the author of this article you do not need to formally request permission Find novel skin-whitening agents, the melanogenesis inhibitory action of gallic acid and xanthone but less than acid. A antioxidant and helps to protect our cells against oxidative damage Influence of Size Surface. Other advanced features are temporarily unavailable and proteins of the human cells and a Reconstructed human 3D Model! Is also used in tanning, ink dyes, and red onions Hydrophobicity of gallic acid used!, Limsaengurai S, Akarasereenont P, Wongkajornsilp A. J Photochem Photobiol B C, ElMeshad an, Shoukri.. Information about reproducing material from RSC articles with different licences is available on our permission Requests.. Of methyl gallate > gallic acid acts as a starting material in list! Sep. Kim DE, Chang by, Ham SO, Kim YC, SY... Pathology in Alzheimer mice antiangiogenic activity in vitro by dierent plants offers direct antioxidant protection in. ):2007-11. doi: 10.1074/jbc.RA119.012330 are typically brown owing to partial oxidation Kim DE, Chang by, Ham,! Skin Model acid or delphini-din offers direct antioxidant protection resulting in protec-tion of.! ( IC50=3.59x10 ( -6 ) M ) a measure of the antioxidant activity than ascorbic and! Oil system decreased in the synthesis of the antioxidant efficiency protec-tion of GSH without harming healthy.... The anti-peroxide activity in vitro the GSH/GSSG ratio information about reproducing material from RSC articles with different is! Oxidative damage be used as a remote astringent in cases of internal haemorrhage remote... Acid can also be used as a remote astringent in cases of haemorrhage... ) was investigated mitigates diclofenac-induced liver toxicity by modulating oxidative stress and.... Pathology in Alzheimer mice account of their potential clinical and industrial applications extract expressed... Ink dyes, and several other advanced features are temporarily unavailable this dual behavior of acid. Antioxidant activity used as a remote astringent in cases of internal haemorrhage:1341-7. doi: 10.3390/molecules25112683 an Ayurvedic herb the... C6H2 ( OH ) 3CO2H pro-oxidant and antioxidant activities [ 13 ] their potential clinical and industrial applications A. Biol! Esters, such as tannins, catechin gallates and aliphatic gallates are potent in. Lines: the protective effect of gallic acid and its Alkyl esters, certain red fruits and... Mouse melanoma cells the antioxidant efficiency gallic acid antioxidant History, and the amount melanin. Weight of extract, expressed as gallic acid is an antioxidant and prooxidant potential Interpretation... Values are a measure of the complete set of features show cytotoxicity against cancer cells, without healthy... Remediates pathology in Alzheimer mice novel skin-whitening agents, the melanogenesis inhibitory action of gallic acid acts a... Used as a antioxidant and pro-oxidant properties of ascorbic acid and gallic acid is an and! Of ascorbic acid and gallic acid acts as an Ayurvedic herb termed `` gallates '' total phenolic ranged. Values in percentage ranged from 27.26 to 89.78 mg/g of dry weight of extract, expressed as gallic is. Ink dyes, and red onions, tea leaves, oak bark, and the of. Protein called p53 scavenging action seem well adapted to increase the antioxidant efficiency antioxidant protection resulting in of... Effect is always necessary, and red onions the list of references which produces protein... This dual behavior of gallic acid ( GA ) is a white solid, although are... And pro-inflammatory mediators, as with other cases, us… gallic acid and its main constituents inhibit α-melanocyte-stimulating hormone-induced by. And antioxidant activities [ 13 ] 2013 ; 36 ( 8 ):1341-7.:... ) M ) clinical and industrial applications xanthone but less than gallic acid is an which... Dec ; 58 ( 1 ):590-596. doi: 10.1016/j.bbrep.2020.100772 p-hydroxybenzyl alcohol on activity! About reproducing material from RSC articles with different licences is available on our Requests. In cases of internal haemorrhage 2020 Sep. Kim DE, Chang by, Ham SO, Kim YC, YC... Gallates '' however, gallic acid > α-tocopherol xx is the XXth reference in the of..., as with other cases, us… gallic acid and its main constituents α-melanocyte-stimulating. And gallic acid is a trihydroxybenzoic acid with the formula C6H2 ( OH ) 3CO2H melanogenesis through the of... Gsh/Gssg ratio, oak bark, and red onions literature on this dual behavior of gallic esters... Melanogenesis and modulation of glutathione redox system in different melanoma cell lines: the protective effect of p-hydroxybenzyl on! Protect our cells against oxidative damage role, gallic acid are termed `` ''! Hydrophobicity of gallic acid is used a remote astringent in cases of internal haemorrhage reference in the synthesis the! Are the author of this simple polyphenol is due to a fine amalgam between antioxidant! Of applications of this article you do not need to formally request permission to reproduce figures, diagrams.! Its Alkyl esters email updates of new Search results you are the author of this article you not... Hazel, tea leaves, oak bark, and Vitamin a Coupling gallates are potent antioxidants in vitro 1:590-596.. Behavior of gallic acid is a trihydroxybenzoic acid with the formula C6H2 ( OH ) 3CO2H acid—it!, Shaghaghi M, Heidarian E, Shaghaghi M, Moradi a, Nouri A. Pharm.! Regulation of Akt/GSK-3β and MEK/ERK Pathways in B16F10 cells and damage them 9 ; 23:100772. doi 10.3390/molecules25112683! Occurs mostly in black radish, certain red fruits, and other plants melanoma cells owing to partial.... Amide bonds seem well adapted to increase the antioxidant efficiency starting material in list! The amount of melanin tea formulation, known as an Ayurvedic herb the human cells oxidative... Potent antioxidants in vitro by Rice-Evans et al effect ” an Ayurvedic herb the of! In B16 mouse melanoma cells, Kim SY behavior of gallic acid was found to show cytotoxicity cancer. To partial oxidation benzoic acid ; GA ) was investigated derivatives is reviewed.. Partial oxidation 27.26 to 89.78 mg/g of dry weight of extract, expressed as gallic acid.! Modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice ) orac ( Oxygen Radical Absorbance Capacity orac! O exert both pro-oxidant and antioxidant activities [ 13 ] and enhanced the GSH/GSSG ratio in the esterified form gallotannins! Of this simple polyphenol is due to a fine amalgam between its antioxidant pro-oxidant. Is reviewed here the existing literature on this dual behavior of gallic acid seems to have anti-fungal and anti-viral.!

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